#217
Drug-induced "vacuolar protein sorting" phenotype in yeast

Jan Zouhar (P.I.: Natasha Raikhel)

"Vacuolar protein sorting" or vps mutants secrete significant amount of vacuolar cargo protein CPY outside the cell. Screen identifies compounds that mimic vps mutations.

NSF: MCB 0515963

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  • Forward Screen yes
  • Target Pathway or Process: vacuolar protein sorting
  • Organism Saccharomyces cerevisae
  • Genotype: InvSc1
  • Tissue and/or Cell Type(s) yeast
  • Sample Age: 2 days
  • Growth Conditions yeast cells exposed to drugs for 2 days at 28C in rich YPD media

In total, 1 compound from 1 library is annotated. Out of these, 0 have a score of 1 or higher, and 0 are annotated as inactive.

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Vacuolar cargo protein CPY is secreted when drugs (represented by coloured stars) modify secretory pathway

#218
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The current screen view is limited to one selected compound. To see the full screen data, click here.
ChemBridge Microformat 6168516
LibraryChemBridge Microformat
ID6168516
Name
FormulaC26H19NO6
Molecular Weight 439.424
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Drug-induced "vacuolar protein sorting" phenotype in yeast

Sortin1

#220
Zouhar J, Hicks G and Raikhel NV, Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis, appeared in Proc Natl Acad Sci U S A, 101(25), pp 101(25).

Drug-induced "vacuolar protein sorting" phenotype in yeast

#117184
  • Bioactivity Data Based on Primary Screenyes
  • Verification in Follow-up Screenyes
  • Additional Verification Experimentsbioactivity in Arabidopsis thaliana
  • Evidence for activitysecretion of vacuolar cargo
  • Concentration Range to Obtain Bioactivity [mg/ml]10mg/L
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Drug-induced "vacuolar protein sorting" phenotype in yeast

Sortins trigger CPY secretion in yeast.

#221
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